Role of cholecystokinin in appetite control and body weight regulation

  title={Role of cholecystokinin in appetite control and body weight regulation},
  author={Tanya J. Little and Michael Horowitz and Christine Feinle-Bisset},
  journal={Obesity Reviews},
Cholecystokinin (CCK), a peptide that is distributed widely throughout the gastrointestinal tract and the central nervous system, has a number of physiological effects including the stimulation of gallbladder contraction and pancreatic and gastric acid secretion, slowing of gastric emptying and suppression of energy intake. This review focuses on current knowledge relating to (i) the effects of CCK on energy intake; (ii) the role for CCK in the pathophysiology of obesity; and (iii) the… 
The Role of Cholecystokinin (CCK) in Eating Behavior
The role of CCK as a satiation signal, its mechanisms of action, and its potential participation in the regulation of body weight are summarized.
Cholecystokinin-induced satiety, a key gut servomechanism that is affected by the membrane microenvironment of this receptor.
The molecular basis for binding natural peptide agonist, binding and action of small molecules within the allosteric pocket, and the impact of cholesterol are reviewed.
Role of the Gastrointestinal Tract in Peptide Hormone Release and Appetite
Pharmacological agonists and antagonists of gut peptides are potentially useful for the management of obesity, type 2 diabetes, gastrointestinal motility disorders, and cachexia of critical illness.
Is the CCK2 receptor essential for normal regulation of body weight and adiposity?
CCK2 receptor deletion was associated with increased body weight and hypothalamic NPY content, but reduced fat masses and plasma leptin and insulin, and increased NPY might contribute to increased food intake in CCK2 receptors knockout mice.
Thylakoids promote release of the satiety hormone cholecystokinin while reducing insulin in healthy humans
The addition of thylakoids to energy-dense food promotes satiety signals and reduces insulin response during a single meal in man.
Mechanisms of CCK signaling from gut to brain.
  • H. Raybould
  • Biology, Psychology
    Current opinion in pharmacology
  • 2007
Peptides and proteins regulating food intake: A comparative view
Recent developments in understanding of mechanisms and signals that regulate energy balance in mammals are summarized, and these are compared to what the authors now know about their orthologues in earlier vertebrates, with a particular focus on bony fishes.
MECHANISMS IN ENDOCRINOLOGY: The gut–brain axis: regulating energy balance independent of food intake
This review examines the recent discoveries about hormones produced in the stomach and gut, which have been reported to regulate food intake and energy expenditure in preclinical models and the association of these gut hormones to eating, energy expenditure, and weight loss after bariatric surgery in humans is discussed.
Glutamate and GABA in Appetite Regulation
The Cerdán group has shown that increased neuronal firing in mice hypothalamus, as triggered by appetite during the feeding-fasting paradigm, may stimulate the use of lactate as neuronal fuel leading to increased astrocytic glucose consumption and glycolysis.


Effects of cholecystokinin on appetite and pyloric motility during physiological hyperglycemia.
It is concluded that the acute effect of exogenous CCK-8 on basal pyloric pressure, but not appetite, is modulated by physiological changes in the blood glucose concentration.
Satiety effects of cholecystokinin in humans.
Biological actions of cholecystokinin
Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans.
This study provides further evidence that CCK is an endogenous physiological satiety signal acting through CCK-A receptor-mediated mechanisms, and Repeated-dose studies comparing hunger and satiety responses after CCK -A receptor blockade in healthy subjects and patients with eating disorders may help clarify the possible involvement of endogenous CCK in these conditions.
Rapid development of tolerance to the behavioural actions of cholecystokinin
No change was detected in either body weight or total daily food consumption at any time point during 2 weeks of intraperitoneally infused CCK, providing the first evidence that rapid and reversible tolerance develops to the actions of a gut peptide.
Satiety effects of a physiological dose of cholecystokinin in humans.
Under the conditions of this study, CCK significantly decreases food intake in humans, and this effect is similar for lean and obeseSubjects showed no differences betweenLean and obese subjects in the satiety effects of CCK.