Role of cholecystokinin-8 in nerve growth factor and nerve growth factor mRNA expression in carrageenan-induced joint inflammation in adult rats.

@article{Manni2002RoleOC,
  title={Role of cholecystokinin-8 in nerve growth factor and nerve growth factor mRNA expression in carrageenan-induced joint inflammation in adult rats.},
  author={Luigi Manni and Thomas Lundeberg and Paola Tirassa and Luigi Aloe},
  journal={Rheumatology},
  year={2002},
  volume={41 7},
  pages={787-92}
}
OBJECTIVES The aim of our study was to investigate the role of cholecystokinin-8 (CCK-8), which is able to induce the synthesis of nerve growth factor (NGF), in the joint inflammation of carrageenan-injected rats. METHODS Adult rats were injected in the ankle joint with carrageenan, with or without CCK-8 or a CCK receptor antagonist (proglumide), and tissue swelling, NGF levels and NGF mRNA expression were assessed. RESULTS Expression of NGF and NGF mRNA increased transiently after… CONTINUE READING
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