Role of chloride ions in modulation of the interaction between von Willebrand factor and ADAMTS-13.

@article{Cristofaro2005RoleOC,
  title={Role of chloride ions in modulation of the interaction between von Willebrand factor and ADAMTS-13.},
  author={Raimondo de Cristofaro and Flora Peyvandi and Roberta Palla and Silvia Lavoretano and Rossana Lombardi and Giuliana Merati and Federica Romitelli and Enrico Di Stasio and Pier M Mannucci},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 24},
  pages={23295-302}
}
The degradation of von Willebrand factor (VWF) depends on the activity of a zinc protease (referred to as ADAMTS-13), which cleaves VWF at the Tyr(1605)-Met(1606) peptide bond. Little information is available on the physiological mechanisms involved in regulation of AD-AMTS-13 activity. In this study, the role of ions on the ADAMTS-13/VWF interaction was… CONTINUE READING