Role of chloride channels in bradykinin-induced guinea pig airway vagal C-fibre activation.

@article{Lee2005RoleOC,
  title={Role of chloride channels in bradykinin-induced guinea pig airway vagal C-fibre activation.},
  author={Min-goo Lee and Donald W Macglashan and B J Undem},
  journal={The Journal of physiology},
  year={2005},
  volume={566 Pt 1},
  pages={205-12}
}
We tested the hypothesis that an ionic current carried by chloride ions contributes to bradykinin (BK)-induced membrane depolarization and activation of vagal afferent C-fibres. In an ex vivo innervated trachea/bronchus preparation, BK (1 microM) consistently produced action potential discharge in vagal afferent C-fibres with receptive fields in the trachea or main stem bronchus. The Ca2+-activated Cl- channel (CLCA) inhibitor, niflumic acid (NFA, 100 microM), significantly reduced BK-induced… CONTINUE READING

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Mentioned Connections BETA
BronchiNo subtypeTrachea
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
TracheaNo subtypeBronchi
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
BronchiSibling in is aTrachea
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
TracheaSibling in is aBronchi
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
BronchiSibling in part ofTrachea
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
TracheaSibling in part ofBronchi
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
In an ex vivo innervated trachea / bronchus preparation , BK ( 1 microM ) consistently produced action potential discharge in vagal afferent C - fibres with receptive fields in the trachea or main stem bronchus .
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