Role of chemokines and cytokines in a reactivation model of arthritis in rats induced by injection with streptococcal cell walls.

@article{Schrier1998RoleOC,
  title={Role of chemokines and cytokines in a reactivation model of arthritis in rats induced by injection with streptococcal cell walls.},
  author={Denis J. Schrier and Ralph C. Schimmer and Craig M. Flory and Daniel KL Tung and Peter A Ward},
  journal={Journal of leukocyte biology},
  year={1998},
  volume={63 3},
  pages={359-63}
}
Intraarticular injection of streptococcal cell wall (SCW) antigen followed by intravenous challenge results in a T cell-mediated monoarticular arthritis ill female Lewis rats. Initial studies showed that this reactivation response to intravenous SCW antigen is dependent on the presence of interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) and that the early phase of swelling is neutrophil-dependent. Neutrophil depletion or passive immunization with antibodies to P-selectin or… CONTINUE READING
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