Role of chemerin/CMKLR1 signaling in adipogenesis and osteoblastogenesis of bone marrow stem cells.

@article{Muruganandan2010RoleOC,
  title={Role of chemerin/CMKLR1 signaling in adipogenesis and osteoblastogenesis of bone marrow stem cells.},
  author={Shanmugam Muruganandan and Alexandra A. Roman and Christopher J. Sinal},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2010},
  volume={25 2},
  pages={222-34}
}
Maintenance of healthy bone mass requires a well-coordinated balance between the ongoing processes of bone formation and bone resorption. Bone-forming osteoblasts derive from resident adult stem cells within bone marrow called bone marrow stromal cells (BMSCs). These BMSCs are multipotent and also can give rise to adipocytes, which do not contribute directly to bone formation but may influence bone remodeling through the release of bioactive signaling molecules. Chemerin is a novel adipocyte… CONTINUE READING

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