Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa

Abstract

Pathogenic protozoa express large amounts of cysteine proteases (CPs) that are structurally and functionally related to the lysosomal papain-like proteases of higher eukaryotes (reviewed in Sajid and McKerrow 2002). In multicellular organisms, papain-like CPs are mainly regulated by endogenous inhibitors of the cystatin superfamily (reviewed in Abrahamson… (More)
DOI: 10.1007/s00436-006-0195-y

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