Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa


Pathogenic protozoa express large amounts of cysteine proteases (CPs) that are structurally and functionally related to the lysosomal papain-like proteases of higher eukaryotes (reviewed in Sajid and McKerrow 2002). In multicellular organisms, papain-like CPs are mainly regulated by endogenous inhibitors of the cystatin superfamily (reviewed in Abrahamson… (More)
DOI: 10.1007/s00436-006-0195-y


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