Role of central neural mechanisms in the regulation of hepatic glucose metabolism.

@article{Nonogaki1997RoleOC,
  title={Role of central neural mechanisms in the regulation of hepatic glucose metabolism.},
  author={Katsunori Nonogaki and Akihisa Iguchi},
  journal={Life sciences},
  year={1997},
  volume={60 11},
  pages={797-807}
}
Central monoamine neurotransmitters affect blood glucose homeostasis. Activation of central cholinergic, noradrenergic histaminergic, and serotonergic neurons rapidly increase hepatic glucose output via the sympathetic nervous system. Acute hyperglycemia is mediated by three distinct pathways: the action of epinephrine on the liver, the action of glucagon on the liver, and the direct innervation of the liver. The relative contribution of these factors to hyperglycemia can be altered by diet and… CONTINUE READING