Role of central nervous system insulin resistance in fetal alcohol spectrum disorders.

@article{Monte2010RoleOC,
  title={Role of central nervous system insulin resistance in fetal alcohol spectrum disorders.},
  author={Suzanne de la Monte and Jack R Wands},
  journal={Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique},
  year={2010},
  volume={17 3},
  pages={
          e390-404
        }
}
Fetal alcohol spectrum disorder (FASD) is the most common preventable cause of mental retardation in the USA. Ethanol impairs neuronal survival and function by two major mechanisms: 1) it inhibits insulin signaling required for viability, metabolism, synapse formation, and acetylcholine production; and 2) it functions as a neurotoxicant, causing oxidative stress, DNA damage and mitochondrial dysfunction. Ethanol inhibition of insulin signaling is mediated at the insulin receptor (IR) level and… CONTINUE READING
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Fetal alcohol spectrum disorders and cognitive functions of young children.

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