Role of central melanocortins in endotoxin-induced anorexia.

  title={Role of central melanocortins in endotoxin-induced anorexia.},
  author={Qinheng Huang and Victor J. Hruby and Jeffrey B. Tatro},
  journal={The American journal of physiology},
  volume={276 3 Pt 2},
Inflammation and microbial infection produce symptoms, including fever, anorexia, and hypoactivity, that are thought to be mediated by endogenous proinflammatory cytokines. Melanocortins are known to act centrally to suppress effects on fever and other sequelae of proinflammatory cytokine actions in the central nervous system, but the roles of melanocortins in anorexia and hypoactivity occurring during the acute phase response are unknown. The present study was designed to determine the effects… CONTINUE READING


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