Role of central dopamine in pain and analgesia.

  title={Role of central dopamine in pain and analgesia.},
  author={Patrick B Wood},
  journal={Expert review of neurotherapeutics},
  volume={8 5},
Recent insights have demonstrated a central role for dopaminergic neurotransmission in modulating pain perception and natural analgesia within supraspinal regions, including the basal ganglia, insula, anterior cingulate cortex, thalamus and periaqueductal gray. In addition, while the participation of serotonin and norepinephrine in spinal descending inhibition of pain is well known, a critical role for dopamine in descending inhibition has also been demonstrated. Decreased levels of dopamine… CONTINUE READING


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