Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit

  title={Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit},
  author={Kuldip D. Dave and Jennifer L. Quinn and John A. Harvey and Vincent J. Aloyo},
  journal={Pharmacology Biochemistry and Behavior},

Serotonin 5-HT2A receptors in the CA1 field of the hippocampus mediate head movements in the rabbit

Results indicate that 5-HT2A receptors located in the CA1 field of the hippocampus mediate a motor movement, head bobs, and that this mediation is functionally related to receptor density.

Intrahippocampal LSD accelerates learning and desensitizes the 5-HT2A receptor in the rabbit, Romano et al.

The slight, short-lived enhancement of learning produced by LSD appears to be due to the development of desensitization of the 5-HT2A receptor within the hippocampus as a result of repeated administration of its agonist (LSD).

The Time-Course for Up- and Down-Regulation of the Cortical 5-Hydroxytryptamine (5-HT)2A Receptor Density Predicts 5-HT2A Receptor-Mediated Behavior in the Rabbit

It is established that the density of 5-HT2A receptors in cortex reflects their functional status and that the time course for the onset and offset of changes in cortical 5- HT2A receptor density was correlated with functional changes.

Behavioral response to emotional stress in rabbits: role of serotonin and serotonin2A receptors

Reduction of central 5-HT levels after treatment with the serotonergic neurotoxin 5,7-DHT significantly decreased novelty-elicited head bobs by 40% compared with those in sham-lesioned rabbits, indicating that5-HT mediates, in part, this behavior.


  • D. Nichols
  • Psychology, Biology
    Pharmacological Reviews
  • 2016
Blood oxygen level–dependent functional magnetic resonance imaging and magnetoencephalography have been employed for in vivo brain imaging in humans after administration of a psychedelic, and results indicate that intravenously administered psilocybin and LSD produce decreases in oscillatory power in areas of the brain’s default mode network.



Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats.

  • D. WillinsH. Meltzer
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1997
The findings suggest that the HTR produced by the direct injection of serotonergic agonists into the medial prefrontal cortex is, in part, mediated by the activation of 5-HT2A receptors, which is consistent with other evidence that suggests a functional antagonism between5-HT1A and 5- HT2A receptor activation.

Similarities in the pharmacology of spontaneous and DOI-induced head-shakes suggest 5HT2A receptors are active under physiological conditions

Abstract Nine monoamine receptor antagonists have been compared for their potency to inhibit both spontaneously occurring and DOI ((1-)2,5-dimethoxy-4-iodophenyl)-2-aminopropane)-induced head-shakes