Role of cell defense against oxidative damage in the resistance of Candida albicans to the killing effect of amphotericin B.

@article{SokolAnderson1988RoleOC,
  title={Role of cell defense against oxidative damage in the resistance of Candida albicans to the killing effect of amphotericin B.},
  author={Marcia L Sokol-Anderson and James E. Sligh and Sanford S. Elberg and Janina Brajtburg and George S. Kobayashi and Gerald Medoff},
  journal={Antimicrobial agents and chemotherapy},
  year={1988},
  volume={32 5},
  pages={702-5}
}
A laboratory-derived mutant of Candida albicans B311 (L) and a clinical isolate (C) of C. albicans, both lacking membrane ergosterol, were less susceptible to amphotericin B (AmB)-induced cell membrane permeability to K+ and lethality than was the wild-type laboratory strain (B311) which contained ergosterol. The resistance of L and C to AmB-induced killing was much greater than the level of resistance to AmB-induced cell membrane permeability. L and C were also less susceptible to killing by… CONTINUE READING