Role of cell and matrix-bound VEGF isoforms in lens development.

@article{SaintGeniez2009RoleOC,
  title={Role of cell and matrix-bound VEGF isoforms in lens development.},
  author={Magali Saint-Geniez and Tomoki Kurihara and Patricia A D'Amore},
  journal={Investigative ophthalmology & visual science},
  year={2009},
  volume={50 1},
  pages={311-21}
}
PURPOSE To determine the role of vascular endothelial growth factor (VEGF) in embryonic eye development and lens differentiation. METHODS Expression of components of the VEGF signaling pathway during lens development and in adults was characterized by beta-galactosidase staining of VEGF-LacZ mice, immunohistochemistry, and real-time (q) PCR. Embryonic eyes from wild-type mice and VEGF120/120 mice were analyzed by light microscopy and immunohistochemistry. VEGF function during lens development… CONTINUE READING

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Lens epithelial cells derived from alphaB-crystallin knockout mice demonstrate hyperproliferation and genomic instability.

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