Role of caveolin and caveolae in insulin signaling and diabetes.

  title={Role of caveolin and caveolae in insulin signaling and diabetes.},
  author={Alex W. Cohen and Terry P. Combs and Phillip E Scherer and Michael Phillip Lisanti},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={285 6},
Caveolae are specialized membrane microdomains present within the plasma membrane of the vast majority of cell types. They have a unique composition in that they are highly enriched in cholesterol, sphingolipids, and their coat proteins the caveolins (-1, -2, and -3). In recent years it has been recognized that caveolae act as signaling platforms, serving as a concentrating point for numerous signaling molecules, as well as regulating flux through many distinct signaling cascades. Although… CONTINUE READING
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