Role of caveolin‐1 in hepatocellular carcinoma arising from non‐alcoholic fatty liver disease

@inproceedings{Takeda2018RoleOC,
  title={Role of caveolin‐1 in hepatocellular carcinoma arising from non‐alcoholic fatty liver disease},
  author={Makoto Takeda and Takanori Sakaguchi and Takanori Hiraide and Yasushi Shibasaki and Yoshifumi Morita and Hirotoshi Kikuchi and Koji Ikegami and Mitsutoshi Setou and Hiroyuki Konno and Hiroya Takeuchi},
  booktitle={Cancer science},
  year={2018}
}
The molecular features of hepatocellular carcinoma arising from non-alcoholic fatty liver disease (NAFLD-HCC) are not well known. In this study, we investigated the mechanism by which NAFLD-HCC survives in a fat-rich environment. We found that caveolin (CAV)-1 was overexpressed in clinical specimens from NAFLD-HCC patients. HepG2, HLE, and HuH-7 HCC cell lines showed decreased proliferation in the presence of the saturated fatty acids palmitic acid and stearic acid, although only HLE cells… CONTINUE READING
BETA

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

The story of HCC in NAFLD: from epidemiology, across pathogenesis, to prevention and treatment.

Cristina Margini, Jean F Dufour
  • Liver international : official journal of the International Association for the Study of the Liver
  • 2016
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

NAFLD, NASH and liver cancer

  • Nature Reviews Gastroenterology &Hepatology
  • 2013
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Diminished viral replication and compartmentalization of hepatitis C virus in hepatocellular carcinoma tissue.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2016
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…