Role of cathepsins in blastocyst hatching in the golden hamster.

@article{Sireesha2008RoleOC,
  title={Role of cathepsins in blastocyst hatching in the golden hamster.},
  author={G. Sireesha and Robert Warren Mason and M. A. Hassanein and Sarah Tonack and Alexander Navarrete Santos and S{\"u}nje Fischer and Polani B. Seshagiri},
  journal={Molecular human reproduction},
  year={2008},
  volume={14 6},
  pages={
          337-46
        }
}
The mammalian embryo is encased in a glycoproteinaceous coat, the zona pellucida (ZP) during preimplantation development. Prior to implantation, the blastocyst must undergo 'hatching' or ZP escape. In hamsters, there is a thinning of the ZP followed by a focal lysis and a complete dissolution of the ZP during blastocyst hatching. Earlier studies from our laboratory have indicated a role for cysteine proteases in the hatching phenomenon. In this study, we tested the effect of specific inhibitors… CONTINUE READING

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