Role of cathepsins in blastocyst hatching in the golden hamster.

  title={Role of cathepsins in blastocyst hatching in the golden hamster.},
  author={G. Sireesha and Robert W. Mason and M. A. Hassanein and Sarah Tonack and Alexander Navarrete Santos and Bernd Fischer and Polani B. Seshagiri},
  journal={Molecular human reproduction},
  volume={14 6},
The mammalian embryo is encased in a glycoproteinaceous coat, the zona pellucida (ZP) during preimplantation development. Prior to implantation, the blastocyst must undergo 'hatching' or ZP escape. In hamsters, there is a thinning of the ZP followed by a focal lysis and a complete dissolution of the ZP during blastocyst hatching. Earlier studies from our laboratory have indicated a role for cysteine proteases in the hatching phenomenon. In this study, we tested the effect of specific inhibitors… CONTINUE READING
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