Role of cathepsin K in normal joints and in the development of arthritis.

@article{SalminenMankonen2007RoleOC,
  title={Role of cathepsin K in normal joints and in the development of arthritis.},
  author={Heli Salminen-Mankonen and Jukka P Morko and E. Vuorio},
  journal={Current drug targets},
  year={2007},
  volume={8 2},
  pages={
          315-23
        }
}
Cysteine cathepsins are a large family of proteolytic enzymes active at acidic pH as found in lysosomes. Since its discovery in 1990's, cathepsin K has been shown to be a key enzyme in osteoclastic bone resorption through its activity in the resorption lacuna. Although characteristic to osteoclasts, the expression of cathepsin K has also been observed at other sites in skeleton. Several recent observations have demonstrated up-regulation of cathepsin K in osteoarthritic cartilage and inflamed… CONTINUE READING

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