Role of cathepsin A and cathepsin C in the regulation of glycosidase activity.

Abstract

Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content. Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity. In this review a current state of knowledge is presented concerning the regulation of selected glycosidases activity by cathepsin A (EC 3.4.16.1) and C (EC 3.4.14.1).

DOI: 10.2478/18692

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Cite this paper

@article{Minarowska2012RoleOC, title={Role of cathepsin A and cathepsin C in the regulation of glycosidase activity.}, author={Alina Minarowska and Łukasz Minarowski and Alicja Karwowska and Anna Justyna Milewska and Marek Gacko}, journal={Folia histochemica et cytobiologica}, year={2012}, volume={50 1}, pages={20-4} }