Role of catecholaminergic mechanisms in the expression of the morphine abstinence syndrome in rats

@article{Herz2004RoleOC,
  title={Role of catecholaminergic mechanisms in the expression of the morphine abstinence syndrome in rats},
  author={A. Herz and J. Bl{\"a}sig and R. Paeschi},
  journal={Psychopharmacologia},
  year={2004},
  volume={39},
  pages={121-143}
}
The effect of various drugs affecting catecholaminergic mechanisms on the precipitated morphine withdrawal syndrome was studied in rats which had developed a medium degree of dependence. Administration of low doses of d-amphetamine, cocaine, and L-Dopa shortly before precipitating withdrawal by levallorphan induced a dose-dependent increase of “dominant” withdrawal signs such as jumping and a decrease of “recessive” signs such as wet dog shaking; signs such as diarrhea and ptosis decreased… Expand
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