Role of catalase in retinal antioxidant defence system: its comparative study among rabbits, guinea pigs, and rats.

@article{Ohta1996RoleOC,
  title={Role of catalase in retinal antioxidant defence system: its comparative study among rabbits, guinea pigs, and rats.},
  author={Yoshiji Ohta and Takashi Yamasaki and Takafumi Niwa and Ken Niimi and Yoshinao Majima and I. Ishiguro},
  journal={Ophthalmic research},
  year={1996},
  volume={28 6},
  pages={336-42}
}
The role of catalase in the retinal antioxidant defence system was examined in rabbits, guinea pigs, and rats with and without prolonged administration of a diet containing 0.4% 3-aminotriazole (3-AT), a catalase inhibitor. When weanling rabbits, guinea pigs, and rats we administered 3-AT for 8, 7, and 10 weeks, respectively, retinal catalase activity was reduced by approximately 50% in all these animals. In the retina of rabbits with 3-AT administration, a decrease in superoxide dismutase (SOD… CONTINUE READING