Role of caspase-independent apoptosis in cardiovascular diseases.


Apoptosis plays an important role in various cardiovascular diseases, and inhibition of cardiac apoptosis shows promise as a therapeutic strategy. Caspase, a critical enzyme in the induction and execution of apoptosis, has been targeted to inhibit apoptosis. However a newly recognized caspase-independent apoptosis pathway may also play an important role in cardiac apoptosis. Yet the mechanism and the potential significance of caspase-independent apoptosis in the heart remain poorly understood. In this paper, we reviewed the literatures on the mechanism of caspase-independent apoptosis and its significance in cardiovascular diseases.


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@article{Bae2008RoleOC, title={Role of caspase-independent apoptosis in cardiovascular diseases.}, author={Soochan Bae and Bhargavi Yalamarti and Peter M. Kang}, journal={Frontiers in bioscience : a journal and virtual library}, year={2008}, volume={13}, pages={2495-503} }