Role of cardiac overexpression of ANG II in the regulation of cardiac function and remodeling postmyocardial infarction.

Abstract

ANG II has a clear role in development of cardiac hypertrophy, fibrosis, and dysfunction. It has been difficult, however, to determine whether these actions are direct or consequences of its systemic hemodynamic effects in vivo. To overcome this limitation, we used transgenic mice with cardiac-specific expression of a transgene fusion protein that releases… (More)

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