Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells.

@article{Marzban2005RoleOC,
  title={Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in \{beta\}-cells.},
  author={Lucy Marzban and Galina Soukhatcheva and C Bruce Verchere},
  journal={Endocrinology},
  year={2005},
  volume={146 4},
  pages={1808-17}
}
Islet amyloid polypeptide (IAPP; amylin) is a peptide hormone that is cosecreted with insulin from beta-cells. Impaired processing of proIAPP, the IAPP precursor, has been implicated in islet amyloid formation in type 2 diabetes. We previously showed that proIAPP is processed to IAPP by the prohormone convertases PC1/3 and PC2 at its carboxyl (COOH) and amino (NH(2)) termini, respectively. In this study, we investigated the role of carboxypeptidase E (CPE) in the processing of proIAPP using… CONTINUE READING

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