• Corpus ID: 24837959

Role of carbohydrate moiety in granulocyte colony stimulating factor.

@article{Sakagami2000RoleOC,
  title={Role of carbohydrate moiety in granulocyte colony stimulating factor.},
  author={Hiroshi Sakagami and Masamichi Tajima and Fumitoshi Takayama and Tsareva Oi and Kaoru Kusama and T Yamamoto and M Saito and J I Murayama},
  journal={Anticancer research},
  year={2000},
  volume={20 4},
  pages={
          2355-9
        }
}
Biological activities of two granulocyte-colony stimulating factor (G-CSF) preparations with (Lenograstim) or without (Filgrastim) sugar moiety were compared. Both G-CSF preparations similarly enhanced the N-Formyl-Met-Leu-Phe-induced-migration of human peripheral blood polymorphonuclear cells, but did not significantly affect the proliferation of human oral tumor cell lines (HSC-2, HSG). However, Lenograstim induced cytotoxicity (accompanied by the production of cytoplasmic vacuoles and large… 

INFLAMMATORY RESPONSE FOLLOWING ABDOMINAL SURGERY AND ITS MODULATION BY RECOMBINANT HUMAN GRANULOCYTE COLONY- STIMULATING FACTOR (RHG-CSF, FILGRASTIM)

The effects of perioperative filgrastim (rhG-CSF) and surgery per se on the postoperative acute phase reaction were studied by assessing leukocyte functions, cytokine levels and tenascin-C (Tn-C) and

Treatment of Breast Cancer with Chemotherapy in Combination with Filgrastim

A cost benefit associated with the use of filgrastim in patients with breast cancer has been realised and may lead to a re-evaluation of the current treatment guidelines.