Role of capsule and suilysin in mucosal infection of complement-deficient mice with Streptococcus suis.

@article{Seitz2014RoleOC,
  title={Role of capsule and suilysin in mucosal infection of complement-deficient mice with Streptococcus suis.},
  author={Maren Seitz and Andreas Beineke and Alena Singpiel and Joerg Willenborg and Pavel Dutow and Ralph Goethe and Peter Valentin-Weigand and Andreas Klos and Christoph Georg Baums},
  journal={Infection and immunity},
  year={2014},
  volume={82 6},
  pages={2460-71}
}
Virulent Streptococcus suis serotype 2 strains are invasive extracellular bacteria causing septicemia and meningitis in piglets and humans. One objective of this study was to elucidate the function of complement in innate immune defense against S. suis. Experimental infection of wild-type (WT) and C3(-/-) mice demonstrated for the first time that the complement system protects naive mice against invasive mucosal S. suis infection. S. suis WT but not an unencapsulated mutant caused mortality… CONTINUE READING

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