Role of capsaicin-sensitive afferent neurons in mucosal blood flow response of rat stomach induced by mild irritants

@article{JiroMatsumoto1992RoleOC,
  title={Role of capsaicin-sensitive afferent neurons in mucosal blood flow response of rat stomach induced by mild irritants},
  author={MA JiroMatsumoto and Koji Takeuchi and BS Dr.KojiUeshima and Susumu Okabe},
  journal={Digestive Diseases and Sciences},
  year={1992},
  volume={37},
  pages={1336-1344}
}
The role of capsaicin-sensitive sensory nerves in gastric mucosal blood flow (GMBF) responses to mild irritants was investigated in the rat stomach mounted on a lucite chamber using hypertonic NaCl and 0.2 N HCl. Exposure of the mucosa to hypertonic NaCl (0.5, 0.75, 1 M) for 10 min caused a reduction in the transmucosal potential difference (PD) in a concentration-related manner, followed by an increase of luminal pH and GMBF. In contrast, mucosal application of 0.2 N HCl caused no or little… CONTINUE READING