Role of cannabinoids in chronic liver diseases.

  title={Role of cannabinoids in chronic liver diseases.},
  author={Anna Parfieniuk and R Flisiak},
  journal={World journal of gastroenterology},
  volume={14 40},
Cannabinoids are a group of compounds acting primarily via CB1 and CB2 receptors. The expression of cannabinoid receptors in normal liver is low or absent. However, many reports have proven up-regulation of the expression of CB1 and CB2 receptors in hepatic myofibroblasts and vascular endothelial cells, as well as increased concentration of endocannabinoids in liver in the course of chronic progressive liver diseases. It has been shown that CB1 receptor signalling exerts profibrogenic and… CONTINUE READING