Role of calmodulin in skeletal muscle sarcoplasmic reticulum.

  title={Role of calmodulin in skeletal muscle sarcoplasmic reticulum.},
  author={Michele Chiesi and Ernesto Carafoli},
  volume={22 4},
Three proteins having Mr of 20 000, 35 000, and 57 000 were phosphorylated by a calmodulin-dependent system in fast skeletal muscle sarcoplasmic reticulum (SR). The 20 000-dalton phosphoprotein was an acidic proteolipid distinct from phospholamban, which was present in cardiac SR preparations. The 57 000-dalton phosphoprotein became phosphorylated very rapidly (t1/2 = 5-10 s at 0 degrees C) and was distinct from calsequestrin and the 53 000-dalton glycoprotein, as judged from the… CONTINUE READING