Role of calcium in the pathway for milk protein secretion and possible relevance for mammary gland physiology.

@article{Burgoyne1998RoleOC,
  title={Role of calcium in the pathway for milk protein secretion and possible relevance for mammary gland physiology.},
  author={Robert D. Burgoyne and Jennifer S. Duncan and Allan W. Sudlow},
  journal={Biochemical Society symposium},
  year={1998},
  volume={63},
  pages={91-100}
}
In an attempt to define control points within the secretory pathway for casein synthesis and secretion, we have examined the role of both cytosolic and intra-organelle Ca2+ in the control of casein synthesis, phosphorylation and secretion. In addition, the possible role of cell volume changes in stretch-activation of Ca2+ signals was examined. Examination of the kinetics of casein secretion from freshly isolated lactating mouse mammary acini showed that a portion of the newly synthesized casein… CONTINUE READING