Role of calcium in protein folding and function of Tva, the receptor of subgroup A avian sarcoma and leukosis virus.

@article{Wang2001RoleOC,
  title={Role of calcium in protein folding and function of Tva, the receptor of subgroup A avian sarcoma and leukosis virus.},
  author={Qing Wang and Klavs Dolmer and Wei Huang and Peter G. W. Gettins and Lijun L Rong},
  journal={Journal of virology},
  year={2001},
  volume={75 5},
  pages={
          2051-8
        }
}
Tva is the cellular receptor for subgroup A avian sarcoma and leukosis virus (ASLV-A). The viral receptor function of Tva is determined by a 40-residue cysteine-rich motif called the LDL-A module. In this study, we expressed and purified the wild-type (wt) Tva LDL-A module as well as several mutants and examined their in vitro folding properties. We found that, as for other LDL-A modules, correct folding and structure of the Tva LDL-A module is Ca2+ dependent. When calcium was present during in… CONTINUE READING
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