Role of calcium in acute hyperthermic myocardial injury.

  title={Role of calcium in acute hyperthermic myocardial injury.},
  author={Thomas H. Everett and Supriya Nath and Carl Lynch and James M Beach and Jeannie Whayne and David E. Haines},
  journal={Journal of cardiovascular electrophysiology},
  volume={12 5},
INTRODUCTION We hypothesized that intracellular calcium overload may play an important role in heat-induced myocardial injury. This postulate was investigated using a model of isolated guinea pig papillary muscle in which resting tension was measured as an indirect indicator of cytosolic free-calcium concentration and the fluorescence changes of Fluo-3 AM dye was measured as a direct indicator of cytosolic free-calcium concentration. METHODS AND RESULTS Excised guinea pig right ventricular… CONTINUE READING