Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor.

@article{Wiedmer1990RoleOC,
  title={Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor.},
  author={Therese Wiedmer and Sanford J Shattil and Michael J Cunningham and Peter J. Sims},
  journal={Biochemistry},
  year={1990},
  volume={29 3},
  pages={
          623-32
        }
}
The role of calcium and intracellular calpains in the expression of platelet prothrombinase activity was investigated. Incubation of gel-filtered platelets with complement proteins C5b-9 resulted in alpha-granule and dense granule secretion and exposure of membrane binding sites for coagulation factors Va and Xa. This was accompanied by the release of microparticles from the cell surface that incorporated plasma membrane glycoproteins GP Ib, IIb, and IIIa and the alpha-granule membrane protein… CONTINUE READING

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