Role of calcitonin receptor-like receptor in colonic motility and inflammation.

@article{Clifton2007RoleOC,
  title={Role of calcitonin receptor-like receptor in colonic motility and inflammation.},
  author={Matthew S. Clifton and Julia J. Hoy and Jen Ping Chang and Prema S. Idumalla and Humera Fakhruddin and Eileen F. Grady and Stephen A Dada and Carlos U. Corvera and Aditi Bhargava},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2007},
  volume={293 1},
  pages={
          G36-44
        }
}
Calcitonin gene-related peptide (CGRP) mediates neurogenic inflammation and modulates intestinal motility. The CGRP receptor is a heterodimer of calcitonin receptor-like receptor (CLR) and receptor-associated modifying protein 1. We used RNA interference to elucidate the specific role of CLR in colonic motility and inflammation. Intramural injection of double-stranded RNA (dsRNA) against CLR (dsCLR) into the colonic wall at two sites caused the spatial and temporal downregulation of CLR in the… CONTINUE READING

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