Role of calcineurin signaling in membrane potential-regulated maturation of cerebellar granule cells.

@article{Okazawa2009RoleOC,
  title={Role of calcineurin signaling in membrane potential-regulated maturation of cerebellar granule cells.},
  author={Makoto Okazawa and Haruka Abe and Michiko Katsukawa and Kouichirou Iijima and Tatsuto Kiwada and Shigetada Nakanishi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 9},
  pages={2938-47}
}
At the early postnatal period, cerebellar granule cells proliferate, differentiate, migrate, and finally form refined synaptic connections with mossy fibers. During this period, the resting membrane potential of immature granule cells is relatively depolarized, but it becomes hyperpolarized in mature cells. This investigation was conducted to examine the role of this alteration in membrane potential and its downstream signaling mechanism in development and maturation of granule cells… CONTINUE READING
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