Role of calcineurin in inhibiting disadvantageous associations.

  title={Role of calcineurin in inhibiting disadvantageous associations.},
  author={James Shaw and Nicholas F Matlovich and Walter J. Rushlow and Peter Cain and Nagalingam Rajakumar},
Calcineurin is an important calcium-dependent phosphatase that is evolutionarily conserved in all studied species, and has been implicated in the consolidation and maintenance of new memories. However, recent evidence has extended the role of calcineurin. In contrast to learning tasks that require behavioral acquisition, extinction tasks that require behavioral inhibition have been shown to be reliant on calcineurin. In the present study, using a Morris water maze, we have demonstrated that… CONTINUE READING

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