Role of cMET in the Development and Progression of Colorectal Cancer

@inproceedings{PrezVargas2013RoleOC,
  title={Role of cMET in the Development and Progression of Colorectal Cancer},
  author={Juan Carlos Samam{\'e} P{\'e}rez-Vargas and Pamela Biondani and Claudia Maggi and Manuela Gariboldi and Annunziata Gloghini and Alessandro Inno and Chiara Costanza Volpi and Ambra Vittoria Gualeni and Maria di Bartolomeo and Filippo de Braud and Alessandra Castano and Ilaria Bossi and Filippo Pietrantonio},
  booktitle={International journal of molecular sciences},
  year={2013}
}
Mesenchymal-epithelial transition (MET) is a member of a distinct subfamily of heterodimeric receptor tyrosine kinase receptors that specifically binds the hepatocyte growth factor (HGF). Binding to HGF leads to receptor dimerization/multimerization and phosphorylation, resulting in its catalytic activation. MET activation drives the malignant progression of several tumor types, including colorectal cancer (CRC), by promoting signaling cascades that mainly result in alterations of cell motility… CONTINUE READING
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