Role of cGMP in hydrogen sulfide signaling.

  title={Role of cGMP in hydrogen sulfide signaling.},
  author={Sofia-Iris Bibli and Guangdong Yang and Zongmin Zhou and Rui Wang and Stavros Topouzis and Andreas Papapetropoulos},
  journal={Nitric oxide : biology and chemistry},
The importance of hydrogen sulfide (H2S) in physiology and disease is being increasingly recognized in recent years. Unlike nitric oxide (NO) that signals mainly through soluble guanyl cyclase (sGC)/cGMP, H2S is more promiscuous, affecting multiple pathways. It interacts with ion channels, enzymes, transcription factors and receptors. It was originally reported that H2S does not alter the levels of cyclic nucleotides. More recent publications, however, have shown increases in intracellular cGMP… CONTINUE READING

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