Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function.

@article{Yoshinaga1991RoleOC,
  title={Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function.},
  author={Kazuya Yoshinaga and Minetaro Ogawa and S I Hayashi and Takahiro Kunisada and Tetsuhiro Fujimoto and Shin-ichi Nishikawa},
  journal={Development},
  year={1991},
  volume={113 2},
  pages={689-99}
}
Recent studies have shown that the dominant white spotting (W) locus encodes the proto-oncogene c-kit, a member of the tyrosine kinase receptor family. One symptom of mice bearing mutation within this gene is sterility due to developmental failure of the primordial germ cells during early embryogenesis. To elucidate the role of the c-kit in gametogenesis, we used an anti-c-kit monoclonal antibody, ACK2, as an antagonistic blocker for c-kit function to interfere with the development of male and… CONTINUE READING
Highly Influential
This paper has highly influenced 20 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 169 extracted citations

Similar Papers

Loading similar papers…