Role of c-kit in mammalian spermatogenesis

@article{Rossi2000RoleOC,
  title={Role of c-kit in mammalian spermatogenesis},
  author={Pellegrino Rossi and Claudio Sette and Susanna Dolci and Raffaele Geremia},
  journal={Journal of Endocrinological Investigation},
  year={2000},
  volume={23},
  pages={609-615}
}
The tyrosine-kinase receptor c-kit and its ligand, stem cell factor (SCF), are essential for the maintenance of primordial germ cells (PGCs) in both sexes. However, c-kit and a postmeiotic- specific alternative c-kit gene product play important roles also during post-natal stages of spermatogenesis. In the adult testis, the c-kit receptor is re-expressed in differentiating spermatogonia, but not in spermatogonial stem cells, whereas SCF is expressed by Sertoli cells under FSH stimulation. SCF… 
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  • J. Dadoune
  • Biology
    Folia histochemica et cytobiologica
  • 2007
The spermatogonial stem cells (SSCs) are at the foundation of spermatogenesis. They can self-renew and generate a large number of differentiated germ cells. A balance between SSC renewal and
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TLDR
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