Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C.

@article{Freemerman1996RoleOC,
  title={Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C.},
  author={Alex J. Freemerman and Anthony J. Turner and Michael J. Birrer and Eva Szab{\'o} and Kristoffer Valerie and Steven Grant},
  journal={Molecular pharmacology},
  year={1996},
  volume={49 5},
  pages={788-95}
}
Recent study results suggest that protein kinase C [PKC (EC 3.1.4.3)] -dependent up-regulation of c-jun may be involved in leukemic cell programmed cell death, or apoptosis, occurring in response to various chemotherapeutic agents. The current study was undertaken to further evaluate the contribution of c-jun in apoptosis with the use of two highly specific pharmacological inhibitors of PKC (calphostin C and chelerythrine). To address this issue, two human leukemic cell lines, HL-60 and U937… CONTINUE READING

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