Role of c-Src in the regulation of vascular contraction and Ca2+ signaling by angiotensin II in human vascular smooth muscle cells.

@article{Touyz2001RoleOC,
  title={Role of c-Src in the regulation of vascular contraction and Ca2+ signaling by angiotensin II in human vascular smooth muscle cells.},
  author={Rhian M Touyz and Xiao Hu Wu and Gang He and Jeong Bae Park and Xiaoping Chen and Jean Vacher and Venkatesh Rajapurohitam and Ernesto L Schiffrin},
  journal={Journal of hypertension},
  year={2001},
  volume={19 3},
  pages={441-9}
}
OBJECTIVE Tyrosine kinases, typically associated with growth-signaling pathways, also play a role in Ang II-stimulated vascular contraction. However the specific kinases involved are unclear. We hypothesize here that c-Src, a non-receptor tyrosine kinase, is an important upstream regulator of vascular smooth muscle cell (VSMC) Ca2+ signaling and associated vascular contraction induced by Ang II. METHODS Cultured VSMCs from resistance arteries of healthy subjects were studied. Human VSMCs… CONTINUE READING

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Src family kinase involvement in rat preglomerular microvascular contractile and [Ca2+]i responses to ANG II.

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Src-family tyrosine kinases and the Ca2+ signal.

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