Role of bundle-forming pilus of enteropathogenic Escherichia coli in host cell adherence and in microcolony development.

@article{Tobe2001RoleOB,
  title={Role of bundle-forming pilus of enteropathogenic Escherichia coli in host cell adherence and in microcolony development.},
  author={Toru Tobe and Chihiro Sasakawa},
  journal={Cellular microbiology},
  year={2001},
  volume={3 9},
  pages={579-85}
}
Enteropathogenic Escherichia coli (EPEC) adheres to epithelial cells and forms microcolonies in localized areas. Bundle-forming pili (BFP) are necessary for autoaggregation and the formation of microcolonies. In this study, we show that BFP, expressed by EPEC on epithelial cells, disappeared with the expansion of the microcolony. Bacterial dispersal and the release of BFP from the EPEC aggregates were induced by contact with host cellular membrane extract. In addition, BFP-expressing EPEC… CONTINUE READING