Role of brain-derived neurotrophic factor in the circadian regulation of the suprachiasmatic pacemaker by light.

@article{Liang2000RoleOB,
  title={Role of brain-derived neurotrophic factor in the circadian regulation of the suprachiasmatic pacemaker by light.},
  author={F Q Liang and Greg Allen and David J. Earnest},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 8},
  pages={2978-87}
}
The central pacemaker located in the suprachiasmatic nucleus (SCN) of the hypothalamus mediates the generation of mammalian circadian rhythms, including an oscillation in pacemaker sensitivity to photic signals conveyed by the retinohypothalamic tract. Because brain-derived neurotrophic factor (BDNF) has been implicated in the functional regulation of neural input to other targets of visual pathways, the present study examined whether changes in BDNF expression or blockade of its action in the… CONTINUE READING

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