Role of brain-derived neurotrophic factor in Huntington's disease

@article{Zuccato2007RoleOB,
  title={Role of brain-derived neurotrophic factor in Huntington's disease},
  author={Chiara Zuccato and Elena Cattaneo},
  journal={Progress in Neurobiology},
  year={2007},
  volume={81},
  pages={294-330}
}
Neurotrophic factors are essential contributors to the survival of peripheral and central nervous system (CNS) neurons, and demonstration of their reduced availability in diseased brains indicates that they play a role in various neurological disorders. This paper will concentrate on the role of brain-derived neurotrophic factor (BDNF) in the survival and activity of the neurons that die in Huntington's disease (HD) by reviewing the evidence indicating that it involves profound changes in BDNF… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 350 references

Dopamine modulates release from corticostriatal terminals.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2004
View 4 Excerpts
Highly Influenced

Mouse and rat BDNF gene structure and expression revisited

Journal of neuroscience research • 2007
View 14 Excerpts
Highly Influenced

Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2006
View 5 Excerpts
Highly Influenced

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain.

The European journal of neuroscience • 2006
View 15 Excerpts
Highly Influenced

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