Role of bradykinin-NO pathway in prevention of cardiac hypertrophy by ACE inhibitor in rat cardiomyocytes.

@article{Ishigai1997RoleOB,
  title={Role of bradykinin-NO pathway in prevention of cardiac hypertrophy by ACE inhibitor in rat cardiomyocytes.},
  author={Yutaka Ishigai and Tomohiro Mori and Toshiko Ikeda and Akiko Fukuzawa and Toshiro Shibano},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1997},
  volume={273 6},
  pages={H2659-H2663}
}
To examine whether the bradykinin-nitric oxide (NO) pathway directly participates in the antihypertrophic property of angiotensin-converting enzyme (ACE) inhibitors in congestive heart failure, the effects of bradykinin were studied in rat cultured heart cells. Bradykinin (0.1, 1 nM) prevented the phenylephrine-induced increase in protein/DNA content, an index of hypertrophy of heart cells, and amplified the nitrite/nitrate content in the medium. Perindoprilat (1 μM), an ACE inhibitor, also… CONTINUE READING