Role of bradykinin B2 receptors in the modulation of the peristaltic reflex of the guinea pig isolated ileum.

@article{Chan2006RoleOB,
  title={Role of bradykinin B2 receptors in the modulation of the peristaltic reflex of the guinea pig isolated ileum.},
  author={Siu Ki Chan and John A Rudd},
  journal={European journal of pharmacology},
  year={2006},
  volume={539 1-2},
  pages={108-15}
}
Bradykinin is well known to have a biphasic action to contract and relax gastrointestinal tissue. However, no studies have investigated the potential action of bradykinin to affect the peristaltic reflex. In the present study, serosally applied bradykinin (1-1000 nM) and the bradykinin B2 receptor agonist, kallidin (1-1000 nM), had inhibitory actions and increased the pressure threshold for peristalsis (maximum changes seen at 1000 nM were approximately 60 Pa), as did morphine (IC50=22.3+/-4.8… CONTINUE READING