Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes.

@article{Xue2014RoleOB,
  title={Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes.},
  author={Ruidan Xue and Yun Wan and Shuo Zhang and Qiongyue Zhang and Hongying Ye and Yiming Li},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2014},
  volume={306 4},
  pages={E363-72}
}
There are two different types of fat present in mammals: white adipose tissue, the primary site of energy storage, and brown adipose tissue, which is specializes in energy expenditure. Factors that specify the developmental fate and function of brown fat are poorly understood. Bone morphogenic proteins (BMPs) play an important role in adipogenesis. While BMP4 is capable of triggering commitment of stem cells to the white adipocyte lineage, BMP7 triggers commitment of progenitor cells to a brown… CONTINUE READING