Role of blood coagulation factor XI in downregulation of fibrinolysis.

@article{Bouma2000RoleOB,
  title={Role of blood coagulation factor XI in downregulation of fibrinolysis.},
  author={Bonno N. Bouma and Joost C M Meijers},
  journal={Current opinion in hematology},
  year={2000},
  volume={7 5},
  pages={266-72}
}
Factor XI is a component of the intrinsic pathway of coagulation. A deficiency of factor XI is associated with a mild to moderate bleeding disorder especially from tissues with a high local fibrinolytic activity. In contrast, high levels of factor XI are a risk factor for venous thrombosis. The recent finding that factor XI can be activated by thrombin led to a revised model of coagulation. In this model the primary thrombin generation that results in fibrin formation takes place via the… CONTINUE READING

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