Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain.

@article{Ohtsuki2002RoleOB,
  title={Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain.},
  author={Sumio Ohtsuki and Hiroshi Asaba and Hitomi Takanaga and Tsuneo Deguchi and Ken-Ichi Hosoya and Masaki Otagiri and Tetsuya Terasaki},
  journal={Journal of neurochemistry},
  year={2002},
  volume={83 1},
  pages={57-66}
}
Renal impairment is associated with CNS dysfunctions and the accumulation of uremic toxins, such as indoxyl sulfate, in blood. To evaluate the relevance of indoxyl sulfate to CNS dysfunctions, we investigated the brain-to-blood transport of indoxyl sulfate at the blood-brain barrier (BBB) using the Brain Efflux Index method. [(3)H]Indoxyl sulfate undergoes efflux transport with an efflux transport rate of 1.08 x 10(-2)/min, and the process is saturable with a Km of 298 microm. This process is… CONTINUE READING
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